HtrA2/Omi, a Sheep in Wolf's Clothing

A sheep in wolf's clothing.

Most are familiar with the biblical warnings about false prophets presenting as the wolf in sheep's clothing, but in this issue of Blood, Mansoor and colleagues expose a sheep in wolf's clothing by shining a bright light on a newly described benign disease previously pretending to be a very bad malignancy, and doing so quite convincingly.

HtrA2/Omi, a Sheep in Wolf's Clothing

Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded protei...

Sheep in Wolf’s Clothing – Enigma Unravelled

Ulcers are common in the oral cavity. A wide spectrum of disorders can give rise to oral ulcers which may range from a local minor trauma to a significant local disease such as a malignancy or any other systemic illness. Early detection and prevention can have a potential impact on the overall incidence, morbidity, and mortality from oral cancers. However the clinical features may sometimes be ...

Eosinophilic Cholangitis and Cholangiopathy: A Sheep in Wolves Clothing

BACKGROUND Eosinophilic cholangitis (EC) is a rare benign disorder of the biliary tract which can cause biliary obstruction. Similar to other disease processes involving the bile ducts, this disorder can pose a difficult diagnostic challenge as it can mimic cholangiocarcinoma. METHODS A systematic search of the scientific literature was carried out using PubMed to access all publications rela...

Reflections: neurology and the humanities: a sheep in wolf 's clothing: a medical student among neurosurgeons.